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Compatibility analysis of 3D printer resin for biological applications @MNL

posted Aug 31, 2016, 1:39 PM by Khaled salama
The salient features of microfluidics such as reduced cost, handling small sample and reagent volumes and less time required to fabricate the devices has inspired the present study.  we report the incompatibility of 3D printer resins in their native form and the method to improve their compatibility to many biological processes via surface modification.  Recently 3D printed microfluidics have contributed substantially regarding cost cutting to the fabrication of advanced lab on-chip devices to biomedical field. The compatibility of the material to build microfluidic devices was evaluated in three different ways (1) determining if the UV cured resin inhibits the polymerase chain reaction (PCR) i.e., testing devices for PCR compatibility and (2) observing agglutination complex formed on the surface of the UV cured resin when anti-CRP antibodies and Creactive protein (CRP) proteins were allowed to agglutinate (3) by culturing human embryonic kidney cell line (HEK) cells and testing for its attachment and viability. This study finds importance in building Lab-on-chip/Micro Total analysis systems (µTAS) and organ-on-chip devices.  

This work is a collaboration with prof. Niveen Khashab. This work was first presented at NEMS 2016 and was invited for a special issue  at the IET Micro and Nano letter. More details can be found at 

Shilpa Sivashankar, Sumeyra Agambayev, kholod alamoudi,  Ulrich Buttner,Niveen Khashab, and Khaled Nabil Salama Compatibility analysis of 3D printer resin for biological applications, micro and nano letters, 2016

Shilpa Sivashankar, Sumeyra Agambayev, Ulrich Buttner, Khaled Nabil Salama, Characterization of Solid UV Curable 3D Printer Resins for Biological Applications, NEMS2016