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Label free, ultrasensitive detection of cancer biomarkers

posted Aug 31, 2018, 10:04 PM by Khaled salama   [ updated Sep 1, 2018, 1:08 PM ]
We continue our strong and fruitful collaboration with prof. Husam Alshareef on using new 2D materials for biosensors. In this work, ultrathin Ti3C2-MXene nanosheets were synthesized by minimally intensive layer delamination methods, and uniformly functionalized with aminosilane (f-Ti3C2-MXene) to provide a covalent binding for the immobilized bio-receptor (anti-CEA) for label free, ultrasensitive detection of cancer biomarker (carcinoembryonic antigen, CEA). We believe that this work opens a new window for development of MXene-based highly sensitive DNA, aptamer, enzyme, antibody, and cell based biosensors, and could be further used in drug delivery application.
Read all about it at:
Saurabh Kumar, Yongjiu Lei, Niman H. Alshareef, M.A. Quevedo-Lopez, Khaled N. Salama "Biofunctionalized Two-Dimensional Ti3C2 MXenes for Ultrasensitive Detection of Cancer Biomarker", Biosensors and Bioelectronics, 2018