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Prof. Pamela Abshire visits KAUST

posted Dec 20, 2017, 9:38 AM by Khaled salama   [ updated Dec 20, 2017, 9:42 AM ]
Prof. Pamela Abshire from the university of Maryland visited KAUST for a week. She served as an external examiner of PhD student Abdulaziz Alhoshani. She gave a seminar at the department and we explored various research opportunities. Of course, we got to visit Jeddah and do some sightseeing :)





Lab on CMOS Biosensors for Hybrid Bioelectronic Systems

By Professor Pamela Abshire (Department of Electrical and Computer Engineering and the Institute for Systems Research at the University of Maryland, College Park)  
 
Lab-on-a-chip (LOC) systems are miniaturized devices that integrate several laboratory functions onto a single “chip”. This subdiscipline of micro-electro-mechanical systems has grown into a large field. The “chips” in LOC systems are usually passive substrates, so most LOC systems are limited to use as passive chips in labs. These chips in labs must typically be used in conjunction with benchtop equipment for sensing and control, missing the opportunity for smaller and more automated systems that would be made possible by replacing those benchtop instruments with miniaturized equivalents. By integrating active electronics into traditional passive LOC systems, a new class of lab-on-CMOS (LOCMOS) systems has emerged – highly integrated multiphysics LOC systems with instrumentation in intimate contact with sensing and actuation capabilities. In such systems, the integrated circuits are often used for sensing and sometimes for signal processing, detection, and actuation as well. This reduces the need for external instrumentation, leading to overall systems with significantly smaller size and also the potential for completely novel measurements that cannot be performed using traditional approaches. This talk will introduce several novel CMOS biosensors that have been designed to monitor the responses of living biological cells directly, including the detection of electrical potential, cell-substrate capacitance, and optical characteristics. The integration of active integrated circuits into LOC systems poses a number of distinct and vexing challenges specifically attributable to biological and fluidic domains (including electrochemistry, packaging, surfaces, sterilization, microfabrication, and microfluidics) and new versions of classical electronics challenges in system-on-chip integration. Finally, we’ll describe the use of LoCMOS in two applications: 1) a nose on a chip that aims to create a hybrid bioelectronic olfactory sensor by combining living olfactory sensory neurons (OSNs) with integrated circuitry that locally detects and processes the electrical signals produced by OSN upon odorant binding; and 2) a cancer box that aims to extend LoCMOS into an implantable diagnostic device to isolate and contain cancer cells for the purpose of measuring their viability and in vivo response to chemotherapeutic agents.
 
 
BIO: Pamela Abshire is a Professor in the Department of Electrical and Computer Engineering and the Institute for Systems Research at the University of Maryland, College Park. She received her PhD from Johns Hopkins University in 2001, and is an expert in low power mixed-signal integrated circuits (IC), adaptive ICs and IC sensors, and CMOS biosensors. Her research focuses on better understanding and exploiting the tradeoffs between performance and resources in natural and engineered systems, including hybrid devices incorporating CMOS, MEMS, optoelectronics, microfluidics, and biological components. She has developed sensors and signal processing circuitry for a variety of applications, including cell-based sensing, high performance imaging, miniature robotics, adaptive data conversion, and closed loop control of MEMS and microfluidic systems. She is the recipient of an NSF CAREER award (2003), the Corcoran Award for Electrical and Computer Engineering education (2004), the Robert E. Kent Teaching Award (2011), the Jimmy H. C. Lin Award for Entrepreneurship (2011), and was named the outstanding faculty member of the Institute for Systems Research (2006). She currently serves on the Emerging Technologies and Research Advisory Committee for the U.S. Department of Commerce and on the Board of Governors for the IEEE Circuits and Systems Society. She was General Co-Chair for the IEEE International Symposium on Circuits and Systems 2017.
 


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