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Saliva-based inkjet printed glucose paper sensor

posted Dec 3, 2018, 9:11 AM by Khaled salama   [ updated Dec 31, 2018, 3:29 AM ]
Inexpensive and easy-to-use diagnostic tools for fast health screening are imperative, especially in the developing world, where portability and affordability are a necessity. Accurate monitoring of metabolite levels can provide useful information regarding key metabolic activities of the body and detect the concomitant irregularities such as in the case of diabetes, a worldwide chronic disease. Today, the majority of daily glucose monitoring tools rely on piercing the skin to draw blood. The pain and discomfort associated with finger pricking have created a global need to develop non-invasive, portable glucose assays. In this work, we develop a disposable analytical device which can measure physiologically relevant glucose concentrations in human saliva based on enzymatic electrochemical detection. We use inkjet-printing technology for the rapid and low-cost deposition of all the components of this glucose sensor, from the electronics to the biorecognition elements, on commercially available paper substrates.  We demonstrate that one month after its fabrication and storage in air-free environment, the sensor maintains its function with only minor performance loss. This fully printed, all-polymer biosensor with its ease of fabrication, accuracy, sensitivity and compatibility with easy-to-obtain biofluids such as saliva aids in the development of next generation low-cost, non-invasive, eco-friendly, and disposable diagnostic tools. 
More details at:
Eloïse Bihar, Shofarul Wustoni, Anna Maria Pappa, Khaled N. Salama, Derya Baran and Sahika Inal, A fully inkjet-printed disposable glucose sensor on papernpj Flexible Electronics10.1038/s41528-018-0044-y2, 1(2018).

Paper sensors remove the sting of diabetic testing