Biosensors

KAUST Research Conference 2019: New Trends in Biosensors and Bioelectronics

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KAUST

The “KAUST Research Conference on New Trends in Biosensors and Bioelectronics” aims to give an overview of the most recent efforts in bioelectronics that tackle the “interface” problem and overcome the limits of the current technologies by generating new materials/architectures/device components. With its truly interdisciplinary nature, this conference will bring scientists from different disciplines together.

BioChips: Leveraging Integrated Electronics for Sensing, Medicine, and Science

Pamela Abshire, Professor, Department of Electrical and Computer Engineering and Institute for Systems Research at the University of Maryland, College Park

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B9 L2 R2322

This talk will provide a brief overview of LoCMOS systems, the technologies used to construct them, and their application to novel applications in biosensing, medical diagnostics, and neuroscience. The integration of integrated circuits into LoCMOS devices poses a number of distinct and vexing challenges, increasing complexity while reducing the need for external instrumentation.

Flexible low-cost cardiovascular risk marker biosensor for point-of-care applications

1 min read ·
Shilpa Sivashankar, et al., "Flexible low-cost cardiovascular risk marker biosensor for point-of-care applications." Electronics Letters 51 (22), 2015, 1746. Abstract: The detection and quantification of protein on a laser written flexible substrate for point-of-care applications are described. A unique way of etching gold on polyethylene terephthalate (PET) substrate is demonstrated by reducing the damage that may be caused on PET sheets otherwise. On the basis of the quantity of the C-reactive protein (CRP) present in the sample, the risk of cardiac disease can be assessed. This hsCRP test

Ocean One: A Robotic Avatar for Oceanic Discovery

1 min read ·
Oussama Khatib, et al., "Ocean one: A robotic avatar for oceanic discovery." IEEE Robotics & Automation Magazine 23 (4), 2016, 20. The promise of oceanic discovery has long intrigued scientists and explorers, whether with the idea of studying underwater ecology and climate change or with the hope of uncovering natural resources and historic secrets buried deep in archaeological sites. This quest to explore the oceans requires skilled human access, yet much of the oceans are inaccessible to human divers; nearly ninetenths of the ocean floor is at 1 km or deeper . Accessing these depths is

A “Twisted” Microfluidic Mixer with “Turbulent” Fluidic Flow for Wide Range of Flowrate Applications

1 min read ·
Sivashankar Shilpa, et al., "A “Twisted” Microfluidic Mixer with “Turbulent” Fluidic Flow for Wide Range of Flowrate Applications." Biomicrofluidics 10, 2016, 034120. This paper proposes a new “twisted” 3D microfluidic mixer fabricated by a laser writing/microfabrication technique. Effective and efficient mixing using the twisted micromixers can be obtained by combining two general chaotic mixing mechanisms: splitting/recombining and chaotic advection. The lamination of mixer units provides the splitting and recombination mechanism when the quadrant of circles is arranged in a two-layered

Integration of fractal biosensor in a digital microfluidic platform

1 min read ·
Yousof Mashraei, et al., "Integration of fractal biosensor in a digital microfluidic platform." IEEE Sensors Journal 16 (24), 2016, 8775. Abstract: The digital microfluidic (DMF) platform introduces many applications in biomedical assays. If it is to be commercially available to the public, it needs to have the essential features of smart sensing and a compact size. In this paper, we report on a fractal electrode biosensor that is used for both droplet actuation and sensing C-reactive protein (CRP) concentration levels to assess cardiac disease risk. Our proposed electrode is the first two

Bio‐Inspired Carbon Monoxide Sensors with Voltage‐Activated Sensitivity

1 min read ·
Savagatrup Suchol, et al. "Bio‐Inspired Carbon Monoxide Sensors with Voltage‐Activated Sensitivity." Angewandte Chemie 129 (45) ,2017, 14254. Carbon monoxide (CO) outcompetes oxygen when binding to the iron center of hemeproteins, leading to a reduction in blood oxygen level and acute poisoning. Harvesting the strong specific interaction between CO and the iron porphyrin provides a highly selective and customizable sensor. We report the development of chemiresistive sensors with voltage‐activated sensitivity for the detection of CO comprising iron porphyrin and functionalized single‐walled

A biosensor-CMOS platform and integrated readout circuit in 0.18-μm CMOS technology for cancer biomarker detection

1 min read ·
Abdulaziz Alhoshany, et al., " A biosensor-CMOS platform and integrated readout circuit in 0.18-μm CMOS technology for cancer biomarker detection". Sensors, 17(9), 2017, 1942. This paper presents a biosensor-CMOS platform for measuring the capacitive coupling of biorecognition elements. The biosensor is designed, fabricated, and tested for the detection and quantification of a protein that reveals the presence of early-stage cancer. For the first time, the spermidine/spermine N1 acetyltransferase (SSAT) enzyme has been screened and quantified on the surface of a capacitive sensor. The sensor

Biofunctionalized Two-dimensional Ti3C2 MXenes for Ultrasensitive Detection of Cancer Biomarker

1 min read ·
Saurabh Kumar, et al., "Biofunctionalized Two-dimensional Ti3C2 MXenes for Ultrasensitive Detection of Cancer Biomarker". Biosensors and Bioelectronics, 121, 2018, 243. In this work, ultrathin Ti3C2-MXene nanosheets were synthesized by minimally intensive layer delamination methods, and uniformly functionalized with aminosilane (f-Ti3C2-MXene) to provide a covalent binding for the immobilized bio-receptor (anti-CEA) for label free, ultrasensitive detection of cancer biomarker (carcinoembryonic antigen, CEA). The effect of different redox probes on the electrochemical behavior of f-Ti3C2-MXene

A fully inkjet-printed disposable glucose sensor on paper

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Eloise Bihar, et al., "A fully Inkjet-printed Disposable Glucose Sensor on Paper". NPJ Flexible Electronics, 2(1), 2018, 1. Inexpensive and easy-to-use diagnostic tools for fast health screening are imperative, especially in the developing world, where portability and affordability are a necessity. Accurate monitoring of metabolite levels can provide useful information regarding key metabolic activities of the body and detect the concomitant irregularities such as in the case of diabetes, a worldwide chronic disease. Today, the majority of daily glucose monitoring tools rely on piercing the

ASIC oriented comparative analysis of biologically inspired neuron models

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El-Maksoud, Ahmed J. Abd, et al. "ASIC oriented comparative analysis of biologically inspired neuron models." 2018 IEEE 61st International Midwest Symposium on Circuits and Systems (MWSCAS). IEEE, 2018, 504. This paper introduces the hardware and the ASIC implementations of the four most popular biologically inspired neuron models. The models are quartic, Izhikevich, Hindmarsh Rose and Fitzhugh-Nagumo. Moreover, some approximate computing techniques are applied on these models to reduce the area and power consumption. In addition, ASIC implementations of these models and their approximate

Memristor-based Synaptic Sampling Machines

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Dolzhikova, I, et al., "Memristor-based Synaptic Sampling Machines. In 2018 IEEE 18th International Conference on Nanotechnology (IEEE-NANO), 2018, 425. Synaptic Sampling Machine (SSM) is a type of neural network model that considers biological unreliability of the synapses. We propose the circuit design of the SSM neural network which is realized through the memristive-CMOS crossbar structure with the synaptic sampling cell (SSC) being used as a basic stochastic unit. The increase in the edge computing devices in the Internet of things era, drives the need for hardware acceleration for data

Deposition of nanomaterials: a crucial step in biosensor fabrication

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Ahmed Rafiq , et al., "Deposition of Nanomaterials: a Crucial Step in Biosensor Fabrication". Materials Today Communications 17, 2018, 289. Biosensor development includes the deposition of (nano)materials onto a conductive electrode surface, which is a crucial step for obtaining improved performance from the constructed biosensors. Various methods have been used to create a successful matrix of (nano)materials that ensures proper contact between the material and electrode surface. The purpose of (nano)material deposition is to provide a high surface area to improve the electroanalytical

Linear and nonlinear feature extraction for neural seizure detection

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Elgammal, M. et al., "Linear and nonlinear feature extraction for neural seizure detection" In 2018 IEEE 61st International Midwest Symposium on Circuits and Systems (MWSCAS), 2018, 795. In this paper, both linear and nonlinear features have been reviewed with linear support vector machine (SVM) classifier for neural seizure detection. The work introduced in the paper includes performance measurement through different metrics: accuracy, sensitivity, and specificity of multiple linear and nonlinear features with linear support vector machine (SVM). A comparison is performed between the

Analysis and verification of identical-order mixed-matrix fractional-order capacitor networks

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Kartci, Aslihan, et al"Analysis and verification of identical-order mixed-matrix fractional-order capacitor networks." In 2018 14th Conference on Ph. D. Research in Microelectronics and Electronics (PRIME), 2018, 277. In the open literature while capacitors are introduced with -90 degrees phase angle, here we described our fabricated polymer composite, mixed matrix, as a fractional- order capacitor (FoC). The effect on phase and pseudo- capacitance using a detailed numerical and experimental study of circuit network connections of three identical-order FoCs is shown. The used devices have

Magneto-Acoustic Resonator for Aquatic Animal Tracking

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Abdullah S. Almansouri, et al., "Magneto-Acoustic Resonator for Aquatic Animal Tracking" IEEE Transactions on Magnetics 55 (2), 2019, 1. Over the past three decades, passive acoustic telemetry has significantly helped marine scientist to study and understand the spatial ecology, migratory behaviors, and mortality rates of aquatic animals. A popular telemetry system consists of two components: an acoustic transmitter tag attached to an aquatic animal and powered by a small battery, and a stationary station that receives the acoustic signals from the tagged animal and determines its location

One-step Synthesis and Decoration of Nickel Oxide Nanosheets with Gold Nanoparticles by Reduction Method for Hydrazine Sensing Application

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Ahmed Rafiq, et al., "One-step Synthesis and Decoration of Nickel Oxide Nanosheets with Gold Nanoparticles by Reduction Method for Hydrazine Sensing Application". Sensors and Actuators B: Chemical, 286, 2019, 139. Morphology, nanoscale features, and tunable properties are the fundamentals of nanomaterials to many applications in use nowadays. Exciting approaches are utilized for developing and exploring new nanomaterials that enable broader impact on a variety of application areas. In this study, we synthesized thin nickel oxide (NiO) nanosheets using wet chemistry process and modified their

Wearable Electronics: An Imperceptible Magnetic Skin (Adv. Mater. Technol. 10/2019)

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Abdullah S. Almansouri, et al., "Wearable Electronics: An Imperceptible Magnetic Skin (Adv. Mater. Technol. 10/2019)." Advanced Materials Technologies 4 (10), 2019, 1970052. In article number 1900493 by Abdullah S. Almansouri, Jurgen Kosel, and co‐workers, a wearable magnetic skin provides remote operation and sensing solutions without the need for wires, on‐chip batteries, etc. Versatile in color and shape and extremely flexible, it can be imperceptible or eye‐catching and paves the way for numerous applications, such as tracking eye movements or contact‐free user‐machine interfaces.

A MXene‐Based Wearable Biosensor System for High‐Performance In Vitro Perspiration Analysis

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Yongjiu Lei, et al., "A MXene‐Based Wearable Biosensor System for High‐Performance In Vitro Perspiration Analysis". Small 15(19), 2019, 1901190. Wearable electrochemical biosensors for sweat analysis present a promising means for noninvasive biomarker monitoring. However, sweat‐based sensing still poses several challenges, including easy degradation of enzymes and biomaterials with repeated testing, limited detection range and sensitivity of enzyme‐based biosensors caused by oxygen deficiency in sweat, and poor shelf life of sensors using all‐in‐one working electrodes patterned by traditional

A Comparison of Artificial Neural Network (ANN) and Support Vector Machine (SVM) Classifiers for Neural Seizure Detection

1 min read ·
Elgammal, M, et al., "A Comparison of Artificial Neural Network (ANN) and Support Vector Machine (SVM) Classifiers for Neural Seizure Detection". IEEE 62nd International Midwest Symposium on Circuits and Systems (MWSCAS) 2019, 646. In this paper, two different classifiers are software and hardware implemented for neural seizure detection. The two techniques are support vector machine(SVM) and artificial neural networks(ANN). The two techniques are pretrained on software and only the classifiers are hardware implemented and tested. A comparison of the two techniques is performed on the levels

KAUST Research Conference 2019: New Trends in Biosensors and Bioelectronics

1 min read ·
The “KAUST Research Conference on New Trends in Biosensors and Bioelectronics” was held in KAUST between the 25th and 27th of February. This yearly event aims to give an overview of the most recent efforts in bioelectronics that tackle the “interface” problem and overcome the limits of the current technologies by generating new materials/architectures/device components. With its truly interdisciplinary nature, this conference will bring scientists from different disciplines together, including Chemistry, Electrical Engineering, Biology, and Material Science, who are at the top of their

A Chitosan Gold Nanoparticles Molecularly Imprinted Polymer Based Ciprofloxacin Sensor

1 min read ·
Sandeep G. Surya, et al., "A Chitosan Gold Nanoparticles Molecularly Imprinted Polymer Based Ciprofloxacin Sensor." RSC Advances 10 (22), 2020, 12823. In this work, we present a novel study on the development of an electrochemical biomimetic sensor to detect the ciprofloxacin (CIP) antibiotic. A chitosan gold nanoparticles decorated molecularly imprinted polymer (Ch-AuMIP) was used to modify the glassy carbon electrode (GCE) for preparation of the sensor. The Ch-AuMIP was characterized to understand various properties like chemical composition, morphology, roughness, and conduction using

Organic field effect transistors (OFETs) in environmental sensing and health monitoring: A review

1 min read ·
Sandeep G. Surya, et al., "Organic Field Effect Transistors (OFETs) in Environmental Sensing and Health Monitoring: A review, Trends in Analytical Chemistry 111, 2019, 27. Abstract: Organic field effect transistors (OFETs) have been the focus of sensing application research during the last two decades. In comparison to their inorganic counterparts, OFETs have multiple advantages such as low-cost manufacturing, large area coverage, flexibility, and readily tunable electronic material properties. To date, various organic semiconductors (OSCs), both polymers and small molecules, have been

A label-free Aptasensor FET Based on Au Nanoparticle Decorated Co3 O4 Nanorods and a SWCNT Layer for Detection of Cardiac Troponin T Protein

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Sandeep G. Surya, et al., "A label-free Aptasensor FET Based on Au Nanoparticle Decorated Co3 O4 Nanorods and a SWCNT Layer for Detection of Cardiac Troponin T Protein." Journal of Materials Chemistry B 8, 2020, 18. Acute myocardial infarction (AMI) is a serious health problem that must be identified in its early stages. Considerable progress has been made in understanding the condition of AMI through ascertaining the role of biomarkers, such as myoglobin, cardiac troponin proteins (T and I), creatine kinase-MB, and fatty acid-binding protein (FABP). A field-effect transistor (FET) is an

Fully Inkjet‐Printed, Ultrathin and Conformable Organic Photovoltaics as Power Source Based on Cross‐Linked PEDOT:PSS Electrodes

1 min read ·
Eloïse Bihar, et al., "Fully Inkjet‐Printed, Ultrathin and Conformable Organic Photovoltaics as Power Source Based on Cross‐Linked PEDOT:PSS Electrodes" Advance Material Technology 2000226 , 2020, 1. Ultra‐lightweight solar cells have attracted enormous attention due to their ultra‐conformability, flexibility, and compatibility with applications including electronic skin or miniaturized electronics for biological applications. With the latest advancements in printing technologies, printing ultrathin electronics is becoming now a reality. This work offers an easy path to fabricate indium tin

Meet KAUST prospective student: Carlos Augusto Zan Malaguti

1 min read ·
Carlos Augusto Zan Malaguti, 23, from Brazil, obtained his bachelor’s degree in electronics and telecommunications engineering from Sao Paulo State University (UNESP). Carlos will join KAUST in the fall of 2020 as an M.S./Ph.D. candidate in the KAUST Sensors Lab under the supervision of Professor Khaled Nabil Salama.

A Compact, Passive Frequency-Hopping Harmonic Sensor Based on a Microfluidic Reconfigurable Dual-Band Antenna

1 min read ·
Liang Zhu, et al., "A Compact, Passive Frequency-Hopping Harmonic Sensor Based on a Microfluidic Reconfigurable Dual-Band Antenna," IEEE Sensors Journal, 2020, 1. We propose here a fully-passive wireless liquid sensor using a harmonic transponder, which comprises a dual-band microstrip antenna reconfigured by different types of liquids injected in a fluidic cavity. Different from traditional radio-frequency (RF) backscatter sensors, the proposed harmonic-transponder sensor (or harmonic sensor) receives frequency-hopped RF monotones and backscatters their second harmonics, with the peak

Growth of large-scale MoS2 nanosheets on double layered ZnCo2O4 for real-time in-situ H2S monitoring in live cells

1 min read ·
Mani Veerappan et al., "Growth of large-scale MoS2 nanosheets on double layered ZnCo2O4 for real-time in-situ H2S monitoring in live cells"Journal of Materials Chemistry B, 2020, 1. There is an urgent need to develop in-situ sensors that monitor the continued release of H2S from biological systems to understand H2S-related pathology and pharmacology. For this purpose, we have developed a molybdenum disulfide supported double-layered zinc cobaltite modified carbon cloth electrode (MoS2–ZnCo2O4–ZnCo2O4) based electrocatalytic sensor. The results of our study suggest that the MoS2–ZnCo2O4–ZnCo2O4

Laser scribed graphene: A novel platform for highly sensitive detection of eletroactive biomolecules

1 min read ·
Abdelghani Ghanam, et al., "Laser scribed graphene: A novel platform for highly sensitive detection of eletroactive biomolecules" Biosensors and Bioelectronics, 2020, 112509. Laser-scribed graphene electrodes (LSGEs) have recently shown a potential for the development of electrochemical biosensors thanks to their electronic properties, porous structures, and large surface area that can support the charge transfer. In this paper, the authors present a comparative study of the electrochemical performances of LSGEs with the conventional screen-printed carbon electrodes (SPCEs) toward the

Coating of Conducting and Insulating Threads with Porous MOF Particles through Langmuir-Blodgett Technique

1 min read ·
Sakandar Rauf, et al., "Coating of Conducting and Insulating Threads with Porous MOF Particles through Langmuir-Blodgett Technique." Nanomaterials 11 (1), 2021, 160. The Langmuir-Blodgett (LB) method is a well-known deposition technique for the fabrication of ordered monolayer and multilayer thin films of nanomaterials onto different substrates that plays a critical role in the development of functional devices for various applications. This paper describes detailed studies about the best coating configuration for nanoparticles of a porous metal-organic framework (MOF) onto both insulating or

Plant probes make sense for sustainable farming

1 min read ·
Ultrathin needles for probing plants could help keep crop health in check.

Yuvaraj Sivalingam

Yuvaraj Sivalingam is a Research Scientist at the Sensors Lab, Computer, Electrical, and Mathematical Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. Education and Early Career He received his M.Sc. in Physics in 2007 from Madurai Kamaraj University, India and in 2009 he received his M.Tech. in Sensor System Technology from VIT University (India), with a project entitled “Studies on the development of compositions for hydrogen sensing applications and their relevant instrumentation’. In 2008-2009 during his M.Tech.

Tutku Beduk

Tutku Beduk is currently a PhD student at the Sensors Lab, in the Material Science and Engineering Department, MSE, King Abdullah University of Science and Technology (KAUST). Education and Early Career Tutku Bedük received her bachelor degree from Middle East Technical University in Chemistry with a High Honor Degree, Turkey in 2016. She also competed her MSc degree in Bilkent University in the field of Chemistry, Turkey in 2018. She is currently a PhD candidate in the Sensor Lab Group under the direction of Prof. Khaled Nabil Salama at King Abdullah University of Science and Technology

Sandeep Surya

Postdoctoral Research Fellow, Sensors
Dr. Sandeep Surya is currently a Post-Doctoral fellow at the Sensors Lab, in the Electrical Engineering Department, CEMSE, King Abdullah University of Science and Technology (KAUST). Education and Early Career Dr. Sandeep G. Surya received his Ph.D. degree from IIT Bombay in 2017. He is currently a Post-Doctoral Fellow with Sensors Lab, CEMSE Division, King Abdullah University of Science and Technology. Prior to this, he was a Research Associate with the Microsystems Technology Research Unit, Fondazione Bruno Kessler, Trento, Italy. His forte is in building platforms for different sensor

Sanjit Majhi

Postdoctoral Research Fellow, Sensors
Sanjit Manohar Majhi has recently joined the Sensors group, as a Postdoctoral fellow. Dr. Majhi currently focused on the synthesis of nanomaterials based on 1D/2D metal oxides for gas and biosensing applications. Education and early career Sanjit Manohar Majhi received his Ph.D. degree from the department of Electronic Information Materials Engineering in Chonbuk National University, South Korea in August 2017. He received his master degree in Chemistry from Utkal University, Bhubaneswar in India in 2008. He joined recently in King Abdullah University of Science and Technology, to work under

Saptami Suresh Shetty

M.S. Student, Bioengineering
Saptami Suresh Shetty is a Biomedical Engineering MS/PhD student at Sensors Lab, King Abdullah University of Science and Technology (KAUST). Her areas of focus include Biosensors, Microfabrication and Biomaterials. Education and Early Career Saptami Suresh Shetty received her bachelor’s degree in Biomedical Engineering from the university Vellore Institute of Technology, India. Research Interests Saptami Suresh Shetty is interested in the development of biosensors for the detection of cancer, using a cancer biomarker, her interest also includes optimizing the biosensing platform and

Murilo Calil Faleiros

M.S. Student, Bioengineering
Murilo Calil Faleiros is a Medical Physicist, currently a Bioengineering Ms/PhD student at Sensors Lab, King Abdullah University of Science and Technology (KAUST). His areas of focus include Organic Electronics, Organic Transistors, Biosensors and Device developments. Education and Early Career Murilo Calil Faleiros received his bachelor’s degree in Medical Physics from University of São Paulo, Brazil. Research Interests Murilo Calil Faleiros is interested in the development of devices for biomedical applications and organic electronics, such as organic field effect transistors and others

Eloise Bihar

Postdoctoral Research Fellow, Sensors
Eloise is a postdoctoral fellow specialized in the field of Printed electronics for biomedical applications. Education and early career Eloise received her M.Sc. in engineering, from Grenoble INP-Pagora, in Grenoble, France, in 2010. She later received her PhD. in bioelectronics from Ecole des Mines de Saint Etienne in France in 2016 under the guidance of Prof. George Malliaras. She is currently working in Prof. Khaled Salama’s group, in collaboration with the groups of Prof. Inal and Prof. Baran. Research Interests Eloise’s current research focuses on the fabrication of printed autonomous

Daísy Camargo Ferreira

M.S. Student, Bioengineering
Daísy Camargo Ferreira is a Medical Physicist, currently a Bioengineering Ms/PhD student at Sensors Lab, King Abdullah University of Science and Technology (KAUST). Her areas of interests are Biosensors, Aptasensors and Point of Care Devices. Education and Early Career Daísy Camargo Ferreira received her bachelor’s degree in Medical Physics from University of São Paulo, Brazil. Research Interests Daísy Camargo Ferreira is interested in the development of biosensors for biomedical applications, such as cancer detection, including aptasensors and point of care devices development and

Carlos Augusto Zan Malaguti

Carlos Augusto Zan Malaguti is an M.S./Ph.D. candidate in the KAUST Sensors Lab under the supervision of Professor Khaled Nabil Salama. Education and Early Career Carlos received his bachelor’s degree in Electronics and Telecommunications Engineering from Sao Paulo State University (UNESP), Brazil, in 2020. During his undergrad, Carlos’ work focused on performance research through electrical characterization of 0.13 um SOI MOSFET devices. In the Summer/Fall of 2019, Carlos was a Visiting Student at KAUST, under the supervision of Professor Muhammad M. Hussain. He worked on nanofabrication

Abdullah Bukhamsin

Abdullah Bukhamsin is a Ph.D. student at the Sensors Lab, in the Bioengineering Department, under the supervision of Professor Khaled Nabil Salama at KAUST. Prior to this, Abdullah obtained an M.S. Degree in Engineering under the supervision of Professor Jurgen Kosel at King Abdullah University of Science and Technology (KAUST). Education and Early Career Abdullah Bukhamsin received his B.Sc. degree in Bioengineering from Rice University (Houston, Texas) in 2018. Following that, he completed his M.Sc. degree in Electrical Engineering from King Abdullah University of Science and Technology

Abdulrahman Aljedaibi

Electrical Engineering PhD student at CEMSE, King Abdullah University of Science and Technology (KAUST).